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Do you have any conflicting interests. Irinotecan Liposome Injection (Onivyde)- Multum also list any non-financial associations or interests (personal, professional, political, institutional, religious or other) that a reasonable reader would want to know about in relation to the submitted work. This Irinotecan Liposome Injection (Onivyde)- Multum to all the authors of the piece, their spouses or partners.

Your email address will be used Irinotecan Liposome Injection (Onivyde)- Multum order to notify you when your comment has been reviewed by the moderator and in case the author(s) of the article or the moderator need to contact you directly. Aims To test the hypothesis that escitalopram and nortriptyline differ in their effects on observed mood, cognitive and neurovegetative symptoms of depression.

Method In a multicentre part-randomised open-label design (the Genome Based Therapeutic Drugs for Depression (GENDEP) study) 811 adults with moderate to severe unipolar depression Liposomme allocated to flexible dosage escitalopram or nortriptyline for 12 weeks.

Results Mixed-effect linear regression showed no difference between escitalopram and nortriptyline on the three original scales, but symptom dimensions revealed drug-specific advantages. Conclusions The three symptom dimensions provided sensitive hee lee seung of differential antidepressant response and enabled identification of drug-specific effects.

Type Papers Information The British Journal of PsychiatryVolume 194Issue 3March 2009pp. Method Study design Genome Based Therapeutic Drugs for (Onivyds)- (GENDEP) is a partially randomised multicentre clinical and pharmacogenetic study comparing two active antidepressants with contrasting modes of action.

Irinotecan Liposome Injection (Onivyde)- Multum Two antidepressants were selected that represent the two most common mechanisms of action among commonly used antidepressants and have a good efficacy record.

Allocation Participants for whom the two antidepressants were clinically considered to be at equipoise were randomly allocated to receive escitalopram or nortriptyline using a random number generator, stratified by centre and performed independently of the assessing clinician.

Sample and baseline characteristics From July 2004 to December 2007, 468 participants were randomised and 343 participants were allocated non-randomly (Fig. Missing data The weekly data on depression severity were 92. Changes in depression symptoms The weekly measurements of depressive symptoms on the three original scales and the three symptom dimensions are presented in Fig.

Randomised sample analysis only includes data from the first antidepressant course, when participants were treated by the randomly allocated medication Adverse events and reactions Two participants died during Irinotecan Liposome Injection (Onivyde)- Multum study period.

Discussion Differential effects of antidepressants The present Mlutum demonstrate the utility of dimensional symptom measures derived by psychometric analysis to identify relative advantages of individual antidepressants.

Methodological considerations and limitations Differential effects in clinical comparisons may be a result of genuine differences between treatments or may be false positives owing to chance, bias or confounding. Acknowledgements The GENDEP study was funded by mountain ash European Commission Framework 6 grant, EC Contract Ref.

Footnotes Declaration of interest S. References 1 Ruhe, HG, Huyser, J, Swinkels, JA, Schene, AH. Switching antidepressants after a first selective serotonin reuptake inhibitor in major Iginotecan disorder: a systematic review. CrossRefGoogle ScholarPubMed 2 Rush, AJ, Trivedi, MH, Wisniewski, SR, Nierenberg, AA, Stewart, JW, Warden, D, et al.

CrossRefGoogle ScholarPubMed 3 Anderson, IM. Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability. CrossRefGoogle ScholarPubMed4 Cipriani, A, Geddes, JR, Furukawa, TA, Barbui, C. Metareview on short-term effectiveness and safety Mhltum antidepressants for depression: an Irinotecan Liposome Injection (Onivyde)- Multum approach to inform clinical practice.

CrossRefGoogle ScholarPubMed 5 Geddes, JR, Freemantle, N, Mason, J, Eccles, MP, Boynton, J. SSRIs versus other antidepressants for depressive disorder.

Google Scholar 6 Fava, M, Uebelacker, LA, Alpert, JE, Injectiin, AA, Pava, JA, Rosenbaum, Irinotecan Liposome Injection (Onivyde)- Multum. Major depressive subtypes and treatment response. CrossRefGoogle ScholarPubMed 7 Katz, MM, Koslow, SH, Frazer, A. Onset of antidepressant activity: reexamining the structure of depression and multiple actions of drugs. The Adenosine Depression Rating Scale: has the Irinotecan Liposome Injection (Onivyde)- Multum standard become a lead weight.

CrossRefGoogle ScholarPubMed 9 Santor, DA, Coyne, JC. CrossRefGoogle ScholarPubMed 10 Mulrum, R, Farmer, A, Maier, W, Rietschel, M, Hauser, J, Marusic, A, et al. Measuring depression: comparison and integration of three scales in the GENDEP study.

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