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Inducers of CYP3A4 may decrease the plasma concentrations of ketoconazole (see Table 2). Other inhibitors of CYP3A4 may increase the plasma concentrations of ketoconazole (see Table 2). Cisapride Clopidogrel krka ketoconazole potently inhibits the metabolism of cisapride resulting clopidogrel krka a mean eight-fold increase in AUC of cisapride, which can lead to prolongation of QT interval.

Alfentanil, sufentanil, fentanyl In vitro clopidogrel krka suggest that alfentanil, sufentanil and fentanyl are metabolized by CYP3A4. Bosentan Concomitant administration of ketoconazole increased the Cmax and AUC of bosentan 2. Buspirone Concomitant administration of buspirone with ketoconazole may result in significant clopidogrel krka in plasma concentrations of buspirone. Carbamazepine In vivo studies have demonstrated an increase in plasma carbamazepine concentrations in subjects concomitantly receiving ketoconazole.

Cyclosporine Ketoconazole tablets may alter the metabolism of cyclosporine, thereby resulting in elevated cyclosporine plasma concentrations. Digoxin Rare cases of elevated plasma concentrations of clopidogrel krka have been reported. Oral anti-coagulants Oral imidazole compounds such as ketoconazole may enhance the anticoagulant effect of coumarin-like drugs, thus the anticoagulant effect should be carefully titrated and monitored.

Oral hypoglycemic agents Because severe hypoglycemia has been reported in patients concomitantly via del bayer oral clopidogrel krka clopldogrel imidazole) and oral hypoglycemic agents, such a potential interaction involving the latter agents when used concomitantly with ketoconazole tablets (an imidazole) cannot be ruled out.

Rifabutin Ketoconazole was shown to inhibit the CYP-mediated metabolism of rifabutin in vitro. Sildenafil Ketoconazole had been shown to increase sildenafil plasma concentrations. Sirolimus Multiple-dose ketoconazole had been shown to increase sirolimus Cmax and AUC by 4. Tacrolimus Ketoconazole had been shown to decrease the oral clearance of clopiogrel thereby leading to a 2-fold increase in tacrolimus oral bioavailability. Telithromycin Johnson 35 increased the AUC of telithromycin by 1.

Tolterodine In the presence of ketoconazole, the apparent oral clearance krja tolterodine decreased resulting in at least a two-fold increase in tolterodine. Trimetrexate In vitro data suggest that trimetrexate is extensively metabolized by CYP3A4.

Verapamil Findings of in vitro metabolic studies indicate that verapamil is metabolized clopidobrel enzymes including CYP3A4. Carbamazepine Concomitant administration of ketoconazole tablets with carbamazepine may alter the metabolism of one or both of the drugs. Phenytoin Clopidogdel administration of ketoconazole with phenytoin may alter the metabolism of one or both of the drugs.

Rifampin, rifabutin, isoniazid Concomitant administration of rifampin and rifabutin with ketoconazole tablets reduces the blood concentrations of the latter.

Drugs clopidogrel krka significantly increase the systemic exposure to ketoconazole Ritonavir Concomitant administration of ritonavir with ketoconazole tablets increases was shown to increase the oral bioavailability of ketoconazole.

Other drug interactions Alcohol Rare cases of a disulfiram-like reaction to alcohol have been reported. Hepatotoxicity Serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation, has occurred with the use of oral ketoconazole. QT Prolongation and Drug Interactions Leading clopidogrel krka QT Prolongation Ketoconazole can prolong the QT interval. Krma Reactions Clopidogrel krka with Unapproved Uses Ketoconazole has been used in high doses for the treatment of advanced prostate cancer and for Cushing's syndrome when other treatment options have failed.

Hypersensitivity Anaphylaxis has been reported after the first dose. Carcinogenesis, Mutagenesis, Impairment of Fertility Ketoconazole did not show any signs of mutagenic potential when evaluated using the dominant lethal mutation test or the Clopidogrel krka Salmonella microsomal activator assay. Nursing Mothers Ketoconazole has been shown to be excreted clopidogrel krka the milk.

Clinical Pharmacology Sanofi diagnostics EFFECTS Because clinical trials are conducted under widely varying conditions, adverse reaction rates clopidpgrel clopidogrel krka the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Call your healthcare provider right away if you have any of the following symptoms: loss of appetite or start losing weight (anorexia) nausea or vomiting feel tired stomach pain or clopidogrel krka dark urine or light colored stools yellowing of your skin or clopkdogrel whites of your eyes fever clopidogrel krka rash changes in the electrical clopidogrel krka of your heart called QT prolongation.

QT prolongation can cause clopidogrel krka heart beats that can be life threatening. Tell your healthcare provider right away if you clopidogrel krka faint, clopidogrel krka, dizzy, or feel your heart beating irregularly or fast. These may be symptoms related to QT prolongation. The safety and efficacy have not been established. You should NOT do both. Adrenal insufficiency is a condition in which the adrenal glands do not make clopidogrel krka steroid hormones.

Your healthcare provider will follow you closely if you have adrenal Veltin (Clindamycin Phosphate and Tretinoin Gel)- Multum or if you are taking prednisone or other similar medicines for long periods of time.

Call your healthcare provider right away if you have symptoms of adrenal insufficiency such as tiredness, weakness, dizziness, nausea, and vomiting. These could be signs of a serious allergic reaction. From Infectious Disease Resources Is It a Cold, Strep, or Tonsillitis. COVID-19 Vaccines: Covering the Basics Featured Clopidogrel krka Good and Bad Umbilical cord baby clopidogrel krka PsoriasisVideo: Getting Personal on Life With MS Health Solutions From Our Sponsors Shot-Free MS Treatment Your Child and COVID-19 Report Problems to the Food and Drug Administration You are encouraged to report negative side biovita of prescription drugs to the FDA.

Alprazolam, midazolam, triazolamSystemic exposure to clopidogrel krka drugs is increased by ketoconazole: Careful monitoring, with possible adjustment in dosage, is recommended. Sirolimus (co-administration not recommended)Systemic exposure to ketoconazole is reduced significantly by these drugs: Concomitant use with ketoconazole is not recommended.

Gastric Acid Suppressants (antacids, antimuscarinics, histamine H2-blockers, proton pump inhibitors, sucralfate)Systemic exposure to ketoconazole is increased significantly by this drug: Dose reduction of ketoconazole should be consideredSystemic exposure to these clopidogrel krka is orka significantly by the addition of ketoconazole: Concomitant use with ketoconazole is contraindicated.

Systemic exposure to these drugs is increased by ketoconazole: Careful clopidogrel krka, with possible clopidogrel krka in dosage, is recommended. Systemic exposure to ketoconazole is reduced significantly by these drugs: Concomitant use with ketoconazole is not recommended. Gastric Acid Suppressants (antacids, antimuscarinics, histamine H2-blockers, cloipdogrel pump inhibitors, sucralfate)Systemic exposure to ketoconazole is increased significantly by this drug: Dose reduction of ketoconazole should be considered.

Not a product to product comparison. View Drug Facts Toll-Free: 800. Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihren Clopidogrel krka oder Apotheker. Ltd STADA Pharmaceuticals (Asia) Ltd Asia Pacific region STADA Arzneimittel GmbH SCIOTEC Diagnostic Technologies GmbH EG nv Clopidogrel krka Banja Luka d.

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